تفاعل #1857547

معادلة التفاعل

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

المذيبات

Brine

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was then heated for 10 h
2. 2
   درجة الحرارةto reflux
3. 3
   أخرىthe organic phase was dried
4. 4
   أخرىevaporated
5. 5
   أخرىto obtain the crude product
6. 6
   أخرىThis was purified by column chromatography

الإجراء التجريبي

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

المصدر