تفاعل #1857546

معادلة التفاعل

hydrochloric acid

1,2,4-Triazole

2-bromo-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

sodium hydride

→

desired material

المردود 80.3%

1-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1,2,4-triazol-1-yl)ethanone

المردود 80.3%

المذيبات

water

THF

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added (3000 mL)
2. 2
   ترشيحThe precipitate was filtered off
3. 3
   غسيلwashed with MTBE
4. 4
   تركيزThe organic phase was then concentrated
5. 5
   ترشيحthe resulting solid was filtered off

الإجراء التجريبي

1,2,4-Triazole (249 g) was added carefully (small portions) to a mixture of sodium hydride (85 g) in THF (6000 mL). After 30 minutes a solution of 2-bromo-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone (1322 g) in THF (500 mL) was slowly added and the mixture was stirred for 150 min. The pH was adjusted to 7 with dil. hydrochloric acid whereupon water was added (3000 mL). The precipitate was filtered off and washed with MTBE. The organic phase was then concentrated and the resulting solid was filtered off to yield the desired material (1008 g).

المصدر