تفاعل #1857541

معادلة التفاعل

4-chlorophenol

2-chloro-4-fluoroacetophenone

potassium carbonate

→

1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةto reflux for 48 h
3. 3
   أخرىthe reaction mixture was partitioned between MTBE and water
4. 4
   استخلاصthe aqueous phase was extracted twice with MTBE
5. 5
   غسيلThe combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water
6. 6
   أخرىdried
7. 7
   أخرىThe solvent was evaporated under reduced pressure
8. 8
   أخرىthe crude material was crystallized from diisopropyl ether

الإجراء التجريبي

A mixture of 4-chlorophenol (186 g), 2-chloro-4-fluoroacetophenone (250 g) and potassium carbonate (238 g) in DMF (960 mL) was heated to reflux for 48 h. After cooling to room temperature, the reaction mixture was partitioned between MTBE and water and the aqueous phase was extracted twice with MTBE. The combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water and dried. The solvent was evaporated under reduced pressure and the crude material was crystallized from diisopropyl ether.

المصدر