تفاعل #1857540
ord-4f24a3ed780b4e6bb05e69fa761dfa67
معادلة التفاعل
2,3,5,6-tetrafluorobenzyl alcohol
(1R,3R)-3-((E)-buta-1,3-dienyl)-2,2-dimethylcyclopropane-1-carboxylic acid
N-methyl imidazole
tosyl chloride
→
oily product
المردود 97.6%
2,3,5,6-tetrafluorobenzyl(1R,3R)-3-((E)-Buta-1,3-dienyl)-2,2-dimethylcyclopropane-1-carboxylate
المردود 97.6%
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىAfter purification on silica gel column with 100/1 (v/v) petroleum ether/ethyl ether as eluent
الإجراء التجريبي
In a similar way to that described in example 1 part b., 2.38 g (14.3 mmol) of (1R,3R)-3-((E)-buta-1,3-dienyl)-2,2-dimethylcyclopropane-1-carboxylic acid are added with 3.4 ml (43 mmol) of N-methyl imidazole dissolved in 43 ml of CH3CN, and reacted with 3.26 g (17.2 mmol) of tosyl chloride dissolved in 19 ml of CH3CN then with 2.6 ml (14.3 mmol) of 2,3,5,6-tetrafluorobenzyl alcohol dissolved in 16 ml of CH3CN. After purification on silica gel column with 100/1 (v/v) petroleum ether/ethyl ether as eluent, 4.58 g of an oily product with an E/Z ratio of 97/3 and a purity equal to 96.1% are obtained.