تفاعل #1857336

معادلة التفاعل

2-octyl-5-amidinoindan hydrochloride

sodium methylate

→

2-octyl-5-(5-octylpyrimidine-2-yl) indan

المردود 104.6%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby refluxing for 18 hours and 20 minutes
2. 2
   أخرىAfter the reaction
3. 3
   درجة الحرارةthe reaction mixture was cooled on an ice water bath
4. 4
   أخرىto precipitate a crystal
5. 5
   ترشيحThe crystal was recovered by filtration
6. 6
   أخرىpurified by silica gel column chromatography (eluent: toluene)
7. 7
   أخرىfollowed by recrystallization from a mixture solvent (acetone/methanol)

الإجراء التجريبي

0.80 g (2.59 mM) of 2-octyl-5-amidinoindan hydrochloride, 0.30 g (5.55 mM) of sodium methylate, 0.62 g (2.73 mM) of α-octyloxy-β-dimethylaminoacrolein and 12 ml of methanol were placed in a 30 ml-round bottomed flask, followed by refluxing for 18 hours and 20 minutes under stirring. After the reaction, the reaction mixture was cooled on an ice water bath to precipitate a crystal. The crystal was recovered by filtration and purified by silica gel column chromatography (eluent: toluene), followed by recrystallization from a mixture solvent (acetone/methanol) to obtain 0.57 g of 2-octyl-5-(5-octylpyrimidine-2-yl) indan (Yield: 50.4%). ##STR133##

المصدر