تفاعل #1843966

معادلة التفاعل

(R)-2-(2, 3-methylenedioxyphenyl) heptylamine

triethylamine

phenyl chloroformate

→

N-phenoxycarbonyl-(R)-2-(2, 3-methylenedioxyphenyl) heptylamine

المردود 98.9%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction mixture was washed with water and saturated saline in this order
2. 2
   تجفيفdried over anhydrous sodium sulfate
3. 3
   أخرىthe solvent evaporated

الإجراء التجريبي

To a mixture of 2.35 g of (R)-2-(2, 3-methylenedioxyphenyl) heptylamine, 1.20 g of triethylamine and 20 ml of ethyl acetate was dropwise added 1.72 g of phenyl chloroformate with ice cooling and stirring, and the resultant mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with water and saturated saline in this order, dried over anhydrous sodium sulfate and the solvent evaporated to give 3.51 g of N-phenoxycarbonyl-(R)-2-(2, 3-methylenedioxyphenyl) heptylamine.

المصدر