تفاعل #1843962

معادلة التفاعل

2, 3-dihydro-2, 2-dimethylbenzofuran-7-carboxylic acid

diphenylphosphoryl azide

triethylamine

(R)-2-(2, 3-methylenedioxyphenyl) heptylamine

→

titled compound

المردود 51.3%

(R)-1-[2-(2, 3-methylenedioxyphenyl) heptyl]-3-(2, 3-dihydro-2, 2-dimethylbenzofuran-7-yl) urea

المردود 51.3%

المذيبات

n-hexane

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool with ice
2. 2
   workup.STIRRINGstirring
3. 3
   ترشيحThe precipitated crystals were filtered
4. 4
   أخرىrecrystallized from ethyl acetate

الإجراء التجريبي

A mixture of 0.90 g of 2, 3-dihydro-2, 2-dimethylbenzofuran-7-carboxylic acid, 1.38 g of diphenylphosphoryl azide, 0.61 g of triethylamine and 12 ml of toluene was stirred at 90° C. for 2 hours and allowed to cool with ice. To this mixture was added a solution of 1.18 g of (R)-2-(2, 3-methylenedioxyphenyl) heptylamine in 10 ml of toluene under ice cooling and stirring, and the resultant mixture was stirred at room temperature for 2 hours and mixed with 30 ml of n-hexane. The precipitated crystals were filtered and recrystallized from ethyl acetate to give 1.02 g of the titled compound.

المصدر