تفاعل #1842134

معادلة التفاعل

(Trimethylsilyl)diazomethane

4-bromo-2-fluoro-5-methyl-benzoic acid

MeOH

→

methyl 4-bromo-2-fluoro-5-methyl-benzoate

المردود 82.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated under reduced pressure
2. 2
   أخرىThe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=40/1)

الإجراء التجريبي

(Trimethylsilyl)diazomethane (4.0 ml, 8.0 mmol, 2 M in Et2O) was added dropwise to a solution of 4-bromo-2-fluoro-5-methyl-benzoic acid (1.88 g, 8.05 mmol) in benzene (7.5 ml)-MeOH (5.6 ml) at 10±2° C. over 10 minutes. The mixture was stirred at room temperature for 30 minutes and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=40/1) to give methyl 4-bromo-2-fluoro-5-methyl-benzoate (1.62 g, 82%).

المصدر