تفاعل #1841

معادلة التفاعل

phenol

potassium carbonate

5-fluoro-2-nitrotoluene

→

2-Nitro-5-phenoxytoluene

المذيبات

N,N-dimethylacetamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at 70°-80° C. for 30 minutes
2. 2
   درجة الحرارةthe mixture was heated at 135°-140° C. for 2 hours
3. 3
   درجة الحرارةafter cooling
4. 4
   تركيزconcentrated in vacuo
5. 5
   workup.ADDITIONthe residue was introduced into ice
6. 6
   ترشيحthe crystalline product was filtered off with suction
7. 7
   غسيلwashed with water
8. 8
   أخرىdried

الإجراء التجريبي

14.1 g (150 mmol) of phenol were dissolved in 120 ml of anhydrous N,N-dimethylacetamide, while stirring, 20.6 g (150 mmol) of finely powdered potassium carbonate were added and the mixture was stirred at 70°-80° C. for 30 minutes. After cooling to 20° C., 23.25 g (18.3 ml, 150 mmol) of 5-fluoro-2-nitrotoluene were added dropwise, the mixture was heated at 135°-140° C. for 2 hours and, after cooling, concentrated in vacuo, the residue was introduced into ice and the crystalline product was filtered off with suction, washed with water and dried, 30 g, melting point 43°-46° C.

المصدر