تفاعل #1836349

معادلة التفاعل

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol

triethylamine

→

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)-propan-2-one

المذيبات

ethyl acetate

DMSO

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter stirring overnight
2. 2
   أخرىfollowed by sulfur trioxide pyridine complex (0.663 mg, 4.17 mmol) an hour
3. 3
   workup.STIRRINGAfter stirring for 1 h
4. 4
   غسيلwashed several times with water

الإجراء التجريبي

Trietheylamine (1.65 ml, 11.8 mmol) was added to a stirring solution of 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol (1.02 g, 2.02 mmol) in DMSO (21 ml). The solution was stirred for 30 minutes before addition of sulfur trioxide pyridine complex (0.659 g, 4.14 mmol). After stirring overnight, additional triethylamine (1.0 ml, 7.17 mmol) was added, followed by sulfur trioxide pyridine complex (0.663 mg, 4.17 mmol) an hour later. After stirring for 1 h, the orange solution was diluted with ˜150 ml ethyl acetate and washed several times with water and then brine.

المصدر