تفاعل #1833637

معادلة التفاعل

water

methyl 5-(benzyloxy)-2-hydroxybenzoate

K2CO3

iodomethane

→

methyl 5-(benzyloxy)-2-methoxybenzoate

المردود 98.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   أخرىcollected the solid
3. 3
   workup.DISSOLUTIONThe solid was dissolved in EtOAc (300 mL)
4. 4
   غسيلwashed with water (50 mL) and brine (100 mL)
5. 5
   تجفيفdried over Na2SO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a mixture of methyl 5-(benzyloxy)-2-hydroxybenzoate (10.6 g, 41.1 mmol) and K2CO3 (11.3 g, 82.2 mmol) in DMF (100 mL) was added iodomethane (2.60 mL, 49.3 mmol) drop wise over 5 minutes. The resulting mixture was stirred at room temperature overnight. The reaction mixture was poured into water (400 mL), filtered, and collected the solid. The solid was dissolved in EtOAc (300 mL), washed with water (50 mL) and brine (100 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure to give methyl 5-(benzyloxy)-2-methoxybenzoate (10.4 g, 98%) as a yellow solid.

المصدر