تفاعل #1833292

ord-d327c70a838940f8847757dab63a700e

معادلة التفاعل

Nc1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)c1
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-amine
O=C(O)c1c(F)cccc1Cl
2-chloro-6-fluorobenzoic acid
O=C(Nc1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)c1)c1c(F)cccc1Cl
title compound
O=C(Nc1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)c1)c1c(F)cccc1Cl
2-Chloro-N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-yl]-6-fluorobenzamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىtRET=1.28 min.

الإجراء التجريبي

The title compound was prepared in a similar fashion to the preparation of example 16, replacing 1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-amine with 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-amine (for a preparation see intermediate 9) and replacing 2,6-dichlorobenzoic acid with 2-chloro-6-fluorobenzoic acid (Aldrich); LCMS (System 3): MH+=470, tRET=1.28 min.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09149462B2uspto-grants-2015_10