تفاعل #1833291

معادلة التفاعل

DIPEA

1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-amine

HATU

2,6-dichlorobenzoic acid

→

title compound

المردود 76.7%

2,6-Dichloro-N-{1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-yl}benzamide

المردود 76.7%

المذيبات

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.WAITleft
2. 2
   workup.WAITthe solution left
3. 3
   workup.WAITto stand for 16 h at ambient temperature
4. 4
   أخرىThe solvent was removed
5. 5
   workup.DISSOLUTIONThe sample was dissolved in 1:1 MeOH
6. 6
   أخرىDMSO (0.6 ml) and purified by MDAP on a standard C18 column (method D)
7. 7
   أخرىThe solvent was evaporated in vacuo

الإجراء التجريبي

A solution of HATU (46 mg, 0.12 mmol) in DMF (200 μl) was added to 2,6-dichlorobenzoic acid (22 mg, 0.11 mmol, Avocado) followed by DIPEA (50 μl, 0.286 mmol) and left to stand for 5 min at ambient temperature. A solution of 1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-amine (Art Chem GmbH; 53 mg, 0.22 mmol) in DMF (200 μl) was then added and the solution left to stand for 16 h at ambient temperature. The solvent was removed using a Genevac. The sample was dissolved in 1:1 MeOH:DMSO (0.6 ml) and purified by MDAP on a standard C18 column (method D) using acetonitrile-water with a TFA modifier. The solvent was evaporated in vacuo using a Genevac to give the title compound (35 mg); LCMS (System 3): MH+=414, tRET=1.18 min.

المصدر