تفاعل #1833290

معادلة التفاعل

2,6-difluoro-N-1H-pyrazol-4-ylbenzamide

intermediate 2

2,6-Difluoro-N-[1-({2-[(phenyloxy)methyl]phenyl}methyl)-1H-pyrazol-4-yl]benzamide

1-(bromomethyl)-4-chloro-2-[(phenylmethyl)oxy]benzene

potassium carbonate

→

title compound

N-[1-({4-Chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-4-yl]-2,6-difluorobenzamide

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe suspension was filtered
2. 2
   غسيلthe residue washed with methanol (1 ml)
3. 3
   أخرىThe filtrate was purified by MDAP (Method A) on Supelcosil ABZ+Plus column
4. 4
   أخرىThe solvent was evaporated in vacuo

الإجراء التجريبي

To 2,6-difluoro-N-1H-pyrazol-4-ylbenzamide (for a preparation see intermediate 2, 52 mg, 0.23 mmol) and potassium carbonate (65 mg, 0.47 mmol) was added a solution of 1-(bromomethyl)-4-chloro-2-[(phenylmethyl)oxy]benzene (74 mg, 0.27 mmol) in DMF (1 ml). The reaction was stirred overnight, under nitrogen and at ambient temperature. The suspension was filtered using a hydrophobic frit and the residue washed with methanol (1 ml). The filtrate was purified by MDAP (Method A) on Supelcosil ABZ+Plus column using acetonitrile-water with a formic acid modifier. The solvent was evaporated in vacuo to give the title compound (33 mg) as a white solid; LCMS (System 1): MH+=454, tRET=3.60 min.

المصدر