تفاعل #1833288

معادلة التفاعل

2,6-Difluoro-N-1H-pyrazol-4-ylbenzamide

potassium carbonate

1-(bromomethyl)-2-(butyloxy)benzene

→

title compound

N-(1-{[2-(Butyloxy)phenyl]methyl}-1H-pyrazol-4-yl)-2,6-difluorobenzamide

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe vial was capped
2. 2
   ترشيحThe reaction mixture was filtered
3. 3
   غسيلwashing with MeOH
4. 4
   أخرىto give a total volume of 1 ml
5. 5
   أخرىThis solution was purified by MDAP Sunfire C18 column (Method B)
6. 6
   أخرىThe solvent was removed

الإجراء التجريبي

2,6-Difluoro-N-1H-pyrazol-4-ylbenzamide (for a preparation see intermediate 2, 45 mg, 0.20 mmol), 1-(bromomethyl)-2-(butyloxy)benzene (for a preparation see intermediate 4, 56 mg, 0.23 mmol) and potassium carbonate (42 mg, 0.30 mmol) were weighed into a vial with a stirrer. DMF (0.5 ml) was added, the vial was capped and the mixture was stirred at ambient temperature for 26 h. The reaction mixture was filtered, washing with MeOH to give a total volume of 1 ml. This solution was purified by MDAP Sunfire C18 column (Method B) using acetonitrile-water with a formic acid modifier. The solvent was removed to give the title compound (25 mg) as a colourless gum; LCMS (System 4): MH+=386, tRET=3.02 min.

المصدر