تفاعل #1833287

معادلة التفاعل

2-Fluoro-6-(trifluoromethyl)benzoyl chloride

methanol

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title product

Methyl 2-fluoro-6-(trifluoromethyl)benzoate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction solution was partitioned between DCM (˜50 mL) and saturated aqueous sodium bicarbonate
2. 2
   استخلاصThe aqueous layer was extracted with further DCM
3. 3
   تجفيفthe combined DCM extracts were dried (sodium sulfate)
4. 4
   أخرىevaporated

الإجراء التجريبي

2-Fluoro-6-(trifluoromethyl)benzoyl chloride (Sigma-Aldrich; 950 mg, 4.19 mmol) was added drop-wise to dry methanol (5 mL) under nitrogen. After 18 hours LCMS indicated that no starting material remained. The reaction solution was partitioned between DCM (˜50 mL) and saturated aqueous sodium bicarbonate. The aqueous layer was extracted with further DCM and the combined DCM extracts were dried (sodium sulfate) and evaporated to give the title product as a colourless liquid (786 mg). This material was used in the next step without further purification. LCMS (System 3): tRET=1.05 min.

المصدر