تفاعل #1833286

معادلة التفاعل

2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

4-Nitropyrazole

potassium carbonate

→

1-{[2-Fluoro-6-(trifluoromethyl)phenyl]methyl}-4-nitro-1H-pyrazole

المذيبات

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthe reaction was left
2. 2
   workup.STIRRINGto stir overnight

الإجراء التجريبي

4-Nitropyrazole (Aldrich; 4.974 g, 44.0 mmol) was dissolved in DMF (100 ml) and potassium carbonate (9.12 g, 66.0 mmol) was added. The reaction mixture was allowed to stir at ambient temperature under nitrogen for approximately 5 minutes. 2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (Aldrich; 11.31 g, 44.0 mmol) in DMF (25 ml) was then added over a period of approximately 5 minutes and the reaction was left to stir overnight.

المصدر