تفاعل #1833270

معادلة التفاعل

2-Methoxyethoxymethyl chloride

4-hydroxybenzaldehyde

K2CO3

→

4-((2-methoxyethoxy)methoxy)benzaldehyde

المردود 80.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىto reach room temperature
2. 2
   أخرىAfter removal of the solvent
3. 3
   workup.DISSOLUTIONthe crude residue was dissolved in EtOAc (50 mL)
4. 4
   غسيلconsecutively washed with water (50 mL) and NaOH (10% aqueous solution, 2×20 mL)
5. 5
   تجفيفThe organic layer was dried over anhydrous Na2SO4
6. 6
   ترشيحfiltered
7. 7
   أخرىAfter removal of the solvent

الإجراء التجريبي

2-Methoxyethoxymethyl chloride (5.10 mL, 45.0 mmol) was slowly added to a mixture of 4-hydroxybenzaldehyde (5.00 g, 40.9 mmol) and K2CO3 (6.20 g, 45.0 mmol) in acetone (70 mL) cooled at 0° C. The mixture was allowed to reach room temperature and stirred for 40 h. After removal of the solvent, the crude residue was dissolved in EtOAc (50 mL) and consecutively washed with water (50 mL) and NaOH (10% aqueous solution, 2×20 mL). The organic layer was dried over anhydrous Na2SO4 and filtered. After removal of the solvent, 6.85 g of 4-((2-methoxyethoxy)methoxy)benzaldehyde were obtained [Rf=0.6 (50% AcOEt/Hexanes), colorless oil, 80% yield], that were used without further purification.

المصدر