تفاعل #1833227

معادلة التفاعل

3,5-Difluoro-2-methoxyphenol

boron tribromide

→

title compound

3,5-Difluorobenzene-1,2-diol

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooling bath was removed
2. 2
   درجة الحرارةThe mixture was cooled to −30° C.
3. 3
   workup.ADDITIONtreated in portions with water (3 mL)
4. 4
   درجة الحرارةwarmed to 20° C
5. 5
   workup.ADDITION6 M HCl (10 mL) and ethyl acetate (30 mL) were added
6. 6
   workup.STIRRINGthe mixture was stirred for 20 min
7. 7
   أخرىto produce two clear phases
8. 8
   استخلاصThe aqueous phase was extracted with ethyl acetate (20 mL)
9. 9
   غسيلthe combined organic phases were washed with saturated NaCl (10 mL)
10. 10
    تجفيفdried (Na2SO4)
11. 11
    أخرىrotary evaporated

الإجراء التجريبي

3,5-Difluoro-2-methoxyphenol (1.0 g, 6.3 mmol, prepared as described in Jones, Lyn H.; Randall, Amy; Barba, Oscar; Selby, Matthew D., Organic & Biomolecular Chemistry 2007, 5, 3431-3433) was dissolved in dry dichloromethane (11 mL), cooled to −20 to −30° C. and treated in portions with boron tribromide (BBr3) solution in dichloromethane (1.0 M; 13 mL, 13 mmol). The cooling bath was removed and the mixture was stirred for 20 h at 20° C. The mixture was cooled to −30° C., treated in portions with water (3 mL) and then warmed to 20° C. 6 M HCl (10 mL) and ethyl acetate (30 mL) were added, and the mixture was stirred for 20 min to produce two clear phases. The aqueous phase was extracted with ethyl acetate (20 mL), and the combined organic phases were washed with saturated NaCl (10 mL), dried (Na2SO4) and rotary evaporated to give the title compound as an oil which solidified upon standing (720 mg, 78%): 1H NMR (400 MHz, CDCl3) δ 6.51 (ddd, J=9.5, 2.8, 2.1 Hz, 1H), 6.45 (ddd, J=10.3, 8.7, 2.9 Hz, 1H), 5.71 (s, 1H), 5.06 (s, 1H); 19F NMR (376 MHz, CDCl3) δ −119.56, −136.16; EIMS m/z 146.

المصدر