تفاعل #1824320

معادلة التفاعل

2,5-dithia cyclohexanone

cysteine decyl ester hydrochloride

triethyl amine

→

S-(2-mercaptoethyl)-N-(2-mercapto-1(decyloxycarbonyl)-ethyl)-mercaptoacetamide

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added
2. 2
   غسيلwashed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution
3. 3
   تجفيفAfter drying above sodium sulfate
4. 4
   أخرىthe solvent is evaporated under reduced pressure
5. 5
   أخرىThe oily residue is crystallized by trituration with diethyl ether

الإجراء التجريبي

13.42 g (0.1 mol) of 2,5-dithia cyclohexanone dissolved in 250 ml of anhydrous dichloromethane are added by dropping, and in an argon atmosphere, to a solution of 29.79 g (0.1 mol) of cysteine decyl ester hydrochloride and 10.12 g (0.1 mol) of triethyl amine in 500 ml of anhydrous dichloromethane. The reaction mixture is kept agitated overnight at room temperature and then washed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution and with water. After drying above sodium sulfate, the solvent is evaporated under reduced pressure. The oily residue is crystallized by trituration with diethyl ether.

المصدر