تفاعل #1815336

معادلة التفاعل

racemic (2′R,3R,4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[2-(2,3-dihydroxy-propoxy)-5-(2-trimethylsilanyl-ethynyl)-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′-dione

NaOH

→

title compound

المردود 86.5%

racemic (2′R,3R,4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[5-ethynyl-2-(2,3-dihydroxy-propoxy)-phenyl]-spiro[3H-indole-3,3′-piperidine]-2,6′-dione

المردود 86.5%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate several times
2. 2
   استخلاصThe combined organic extract
3. 3
   تجفيفwas dried over MgSO4
4. 4
   تركيزconcentrated

الإجراء التجريبي

To a stirred solution of racemic (2′R,3R,4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[2-(2,3-dihydroxy-propoxy)-5-(2-trimethylsilanyl-ethynyl)-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′-dione (7.8 mg, 0.013 mmol) in MeOH (3 ml) was added 2N NaOH (1 mL) dropwise. The reaction mixture was stirred at room temperature for 30 min and then extracted with ethyl acetate several times. The combined organic extract was dried over MgSO4 and concentrated to give the title compound as a white solid (6.2 mg). MS (H+), 551

المصدر