تفاعل #1810826

معادلة التفاعل

2-chloro-5-methanesulfonyl-benzoic acid

morpholine

→

5-Methanesulfonyl-2-morpholin-4-yl-benzoic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated for 16 h to 100° C
2. 2
   أخرىAfter evaporation of all volatiles the residue
3. 3
   أخرىsubjected to reversed phase HPLC purification
4. 4
   غسيلeluting with an acetonitrile/water gradient
5. 5
   أخرىto yield
6. 6
   أخرىafter evaporation of the product fractions the title compound

الإجراء التجريبي

A mixture of 163.8 mg (0.7 mmol) 2-chloro-5-methanesulfonyl-benzoic acid (example 4 step b) in 2 ml morpholine was heated for 16 h to 100° C. After evaporation of all volatiles the residue was taken up in 2 ml methanol/formic acid 3/1 and subjected to reversed phase HPLC purification eluting with an acetonitrile/water gradient to yield after evaporation of the product fractions the title compound. MS (m/e): 284.1 (M−H, 100%)

المصدر