تفاعل #1810816

معادلة التفاعل

thionylchloride

2-morpholin-4-yl-5-nitro-benzoic acid

→

title compound

المردود 93.0%

2-Morpholin-4-yl-5-nitro-benzoyl chloride

المردود 93.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   ترشيحfiltered
3. 3
   أخرىdried

الإجراء التجريبي

To a suspension of 2-morpholin-4-yl-5-nitro-benzoic acid (4.0 g, 16 mmol) in toluene were added 2 drops of DMF and thionylchloride (5.7 ml, 79.3 mmol). The mixture was heated to 80° C. for 50 minutes. The solvent was removed in vacuo, and the resulting solid was stirred in ether, filtered and dried to provide the title compound (4.0 g, 93%) as a yellow solid.

المصدر