تفاعل #1810815

معادلة التفاعل

2-fluoro-5-nitrobenzoic acid

morpholine

→

title compound

المردود 93.0%

2-Morpholin-4-yl-5-nitro-benzoic acid

المردود 93.0%

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   ترشيحThe solid was filtered
4. 4
   غسيلwashed with water
5. 5
   أخرىdried

الإجراء التجريبي

To a solution of 2-fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).

المصدر