تفاعل #1810810

ord-358755067df943e3b6940451c3eff180

معادلة التفاعل

CN(C(N)=S)[C@H]1CC[C@H](N)CC1
1-(trans-4-aminocyclohexyl)-1-methyl-thiourea
Cl
hydrochloride
CI
methyliodide
Cl
hydrochloride
I
hydroiodide
CSC(=N)N(C)[C@H]1CC[C@H](N)CC1
1-(trans-4-aminocyclohexyl)-1,2-dimethyl-isothiourea

المذيبات

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    درجة الحرارةis refluxed for 2 hours
  2. 2
    أخرىsolvent is evaporated

الإجراء التجريبي

A mixture of 0.6 g of 1-(trans-4-aminocyclohexyl)-1-methyl-thiourea in the form of a hydrochloride in 30 ml of MeOH and 0.22 ml of methyliodide is refluxed for 2 hours, solvent is evaporated and 1-(trans-4-aminocyclohexyl)-1,2-dimethyl-isothiourea in the form of a hydrochloride and a hydroiodide is obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07485632B2uspto-grants-2009_02