تفاعل #1810809

معادلة التفاعل

[4-(1,2,3-trimethyl-isothioureido)-cyclohexyl]carbamic acid benzylester

hydroiodide

chloride

EtOH

hydrazine monohydrate

→

[4-(3-Amino-1,2-dimethyl-guanidino)-cyclohexyl]-carbamic acid benzylester

hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىA suspension obtained
2. 2
   ترشيحis filtered
3. 3
   أخرىthe filtrate obtained
4. 4
   أخرىThe mixture obtained
5. 5
   درجة الحرارةis refluxed for 2.5 hours and from the mixture
6. 6
   أخرىobtained solvent
7. 7
   أخرىis evaporated

الإجراء التجريبي

0.84 g of [4-(1,2,3-trimethyl-isothioureido)-cyclohexyl]carbamic acid benzylester in the form of a hydroiodide are stirred with 10 ml of of a strong basic ion exchanger in chloride form. A suspension obtained is filtered and the filtrate obtained is lyophilized. The lyophilisate is treated with 15 ml of EtOH and with 0.08 ml of hydrazine monohydrate. The mixture obtained is refluxed for 2.5 hours and from the mixture obtained solvent is evaporated. [4-(3-Amino-1,2-dimethyl-guanidino)-cyclohexyl]-carbamic acid benzylester in the form of a hydrochloride is obtained.

المصدر