تفاعل #1810006

معادلة التفاعل

reactin

sulfonyl chloride

methylene chloride

1-(benzyl)piperazine

→

title compound

المردود 33.0%

1-(9H-Fluoren-2-ylsulfonyl)-4-(phenylmethyl)piperazine, hydrochloride

المردود 33.0%

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   غسيلthe methylene chloride layer is washed with water
2. 2
   تجفيفdried over anhydrous Na2SO4
3. 3
   أخرىEvaporation of the methylene chloride under reduced pressure
4. 4
   أخرىaffords crude product which
5. 5
   أخرىis purified by HPLC
6. 6
   أخرىThe desired fractions (Rf =0.8) are evaporated
7. 7
   أخرىto give pure free base which

الإجراء التجريبي

The title compound is prepared by adding to a stirred solution of the above sulfonyl chloride intermediate (4 g, 0.015 mol) in 50 mL of methylene chloride (2.7 g, 0.015 mol), 1-(benzyl)piperazine (2.7 g, 0.015 mol) and triethylamine (6 mL). The reactin mixture is stirred overnight and the methylene chloride layer is washed with water and dried over anhydrous Na2SO4. Evaporation of the methylene chloride under reduced pressure affords crude product which is purified by HPLC using silica gel column and ethyl acetate as the eluent. The desired fractions (Rf =0.8) are evaporated to give pure free base which is converted to the hydrochloride salt; m.p. 274°-275° C. (33% yield).

المصدر