تفاعل #1797261

معادلة التفاعل

3-[3-(Piperidinomethyl)phenoxy]propylamine

2-bromopyridine

→

title compound

2-[3-[3-(Piperidinomethyl)phenoxy]propylamino]pyridine

المذيبات

chloroform methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooled reaction mixture

الإجراء التجريبي

3-[3-(Piperidinomethyl)phenoxy]propylamine (20 g) and 2-bromopyridine (12.64 g) were stirred at 125° C. for 31/2 days. The cooled reaction mixture was subjected to column chromatography on silica ((chloroform:methanol 10:1) to afford the title compound as an oil. This was treated with maleic acid in ethanol to give, on addition of diethyl ether, as a white solid 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]pyridine dimaleate (11.40 g), m.p. 116°-7° C. (recrystallised from isopropanol).

المصدر