تفاعل #1797256

معادلة التفاعل

3-[3-(piperidinomethyl)phenoxy]propylamine

triethylamine

2-chlorobenzoxazole

→

title compound

المردود 86.5%

2-[3-[3-(Piperidinomethyl)phenoxy]propylamino]benzoxazole

المردود 86.5%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred at room temperature for 16 hours
2. 2
   أخرىevaporated under reduced pressure

الإجراء التجريبي

To 3-[3-(piperidinomethyl)phenoxy]propylamine (0.28 g) and triethylamine (0.40 g) in ethanol (2 ml), at 0° C., under nitrogen, was added 2-chlorobenzoxazole (0.17 g). The reaction mixture was stirred for one hour at 0° C., stirred at room temperature for 16 hours, evaporated under reduced pressure and subjected to column chromatography on silica (chloroform:methanol 25:1) to give the title compound as an oil (0.35 g). This was treated with anhydrous oxalic acid (2.1 equivalents) in methanol (5 ml). Addition of diethyl ether gave 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]benzoxazole dioxalate (0.245 g), m.p. 172°-4° C. (recrystallised from isopropanol-ethyl acetate).

المصدر