تفاعل #1788

معادلة التفاعل

2,4-dimethyl-3-hydroxymethylpyridine

thionyl chloride

→

2,4-dimethyl-3-chloromethylpyridine

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   أخرىthe residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate
3. 3
   تجفيفThe organic layer was dried with MgSO4
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

The 2,4-dimethyl-3-hydroxymethylpyridine (19.2 g, 140 mmol) was dissolved in CH2Cl2 (800 mL) and cooled under nitrogen to 0° C. and thionyl chloride (125 mL) was slowly added and the reaction was stirred for 18 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was dried with MgSO4, filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-chloromethylpyridine.

المصدر