تفاعل #1782827

معادلة التفاعل

rac-2-chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide

rac-2-Chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide

1-methylpiperazine

→

title compound

المردود 77.3%

rac-N-[2-(7-Methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-2-(4-methyl-piperazin-1-yl)-acetamide

المردود 77.3%

المذيبات

acetonitrile

ظروف التفاعل

الإجراء التجريبي

Prepared from rac-2-chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 55 step A) (100 mg, 0.259 mmol) and 1-methylpiperazine (0.289 ml 2.595 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a light yellow foam (90 mg, 77%), MS (ISP) m/e=450.2 [(M+H)+].

المصدر