تفاعل #1782809

معادلة التفاعل

rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine

rac-(6-Bromo-4H-benzo[d][1,3]oxazin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine

2-amino-4-trifluoromethyl-pyrimidine

→

title compound

المردود 59.0%

rac-N2-(4-Methoxy-2,3-dihydro-benzofuran-3-yl)-N6-(4-trifluoromethyl-pyrimidin-2-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine

المردود 59.0%

ظروف التفاعل

الإجراء التجريبي

The title compound (135 mg, 59%), yellow foam, MS (ISP): m/e=458.2 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine (example 54) (188 mg, 0.5 mmol) and commercially available 2-amino-4-trifluoromethyl-pyrimidine (163 mg, 1.0 mmol).

المصدر