تفاعل #1782807

معادلة التفاعل

rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(5-fluoro-indan-1-yl)-amine

rac-(6-Bromo-4H-benzo[d][1,3]oxazin-2-yl)-(5-fluoro-indan-1-yl)-amine

2-amino-4-trifluoromethyl-pyrimidine

→

title compound

المردود 51.0%

rac-N2-(5-Fluoro-indan-1-yl)-N6-(4-trifluoromethyl-pyrimidin-2-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine

المردود 51.0%

ظروف التفاعل

الإجراء التجريبي

The title compound (113 mg, 51%), yellow foam, MS (ISP): m/e=444.2 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(5-fluoro-indan-1-yl)-amine (Example 53) (181 mg, 0.5 mmol) and commercially available 2-amino-4-trifluoromethyl-pyrimidine (163 mg, 1.0 mmol).

المصدر