تفاعل #1782773

معادلة التفاعل

ethyl acetate

rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine

rac-N2-(7-Methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine

methoxyacetyl chloride

ethyl acetate

→

title compound

المردود 73.0%

rac-2-Methoxy-N-[2-(4-methoxy-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide

المردود 73.0%

المذيبات

sodium hydrogen carbonate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   تجفيفdried the organic layer over sodium sulfate
3. 3
   ترشيحAfter filtration
4. 4
   أخرىthe solvent was removed in vacuum
5. 5
   أخرىthe crude product was triturated with diethyl ether

الإجراء التجريبي

To a solution of rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (100 mg, 0.321 mmol) in ethyl acetate (5 ml) and sat. sodium hydrogen carbonate-sol. at 0° C. was added methoxyacetyl chloride (35 ul, 0.385 mmol) and the mixture was stirred at 23° C. for 16 h. Diluted with ethyl acetate, washed with water, dried the organic layer over sodium sulfate. After filtration, the solvent was removed in vacuum and the crude product was triturated with diethyl ether to give the title compound as a white solid (90 mg, 73%), MS (ISP) m/e=384.2 [(M+H)+].

المصدر