تفاعل #1782757

معادلة التفاعل

4-bromo-N-indan-2-yl-4-fluoro-benzamide

para-fluorostyrene

HCl

→

4-fluoro-N-{4-[2-(4-fluoro-phenyl)-vinyl]-indan-2-yl}-benzamide

المردود 90.0%

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 9 h
2. 2
   استخلاصthe mixture extracted with ethyl acetate
3. 3
   أخرىthe resulting solution dried
4. 4
   أخرىevaporated to dryness
5. 5
   أخرىThe residual oil was purified

الإجراء التجريبي

150 mg (0.45 mmoles) 4-bromo-N-indan-2-yl-4-fluoro-benzamide, 1 mg palladium-(II)-acetate, 3.4 mg tri-o-tolyl phosphine and 88 mg (0.72 mmoles) para-fluorostyrene were combined in 2 ml triethylamine and stirred under reflux for 9 h. Subsequently, the reaction mixture was poured on a mixture of ice and diluted HCl, the mixture extracted with ethyl acetate and the resulting solution dried and evaporated to dryness. The residual oil was purified using prep. HPLC chromatography. (RP18, acetonitrile/water, 1% trifluoroacetic acid). 152 mg (90%) 4-fluoro-N-{4-[2-(4-fluoro-phenyl)-vinyl]-indan-2-yl}-benzamide were obtained.

المصدر