تفاعل #1782

معادلة التفاعل

2-ethyl-3-hydroxymethylpyridine

thionyl chloride

→

2-ethyl-3-chloromethylpyridine

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   أخرىthe residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL)
3. 3
   تجفيفThe organic layer was dried with MgSO4
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

The 2-ethyl-3-hydroxymethylpyridine (2.3 g, 16.8 mmol) was dissolved in CH2Cl2 (100 mL) and cooled under nitrogen to 0° C. and thionyl chloride (7.0 mL) was slowly added and the reaction was stirred for 3 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried with MgSO4, filtered, and the solvent removed under reduced pressure to give the desired 2-ethyl-3-chloromethylpyridine.

المصدر