تفاعل #1779953

معادلة التفاعل

5-Chloro-2-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine

3-(4,4,5,5-tetramethyl-1,3,2,-dioxaborolan-2-yl)quinoline

→

112

المردود 46.0%

4-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-5-(quinolin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine

المردود 46.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by reverse phase HPLC

الإجراء التجريبي

5-Chloro-2-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine (130 mg) was reacted with 92 mg of 3-(4,4,5,5-tetramethyl-1,3,2,-dioxaborolan-2-yl)quinoline via General Procedure A. The product was purified by reverse phase HPLC to yield 72.6 mg of 112. MS (Q1) 526.2 (M)+.

المصدر