تفاعل #1772997

معادلة التفاعل

Ethyl 2-{4-[hydroxy(2-oxothiolan-3-yl)methyl]phenyl}propionate

p-toluenesulfonic acid

→

title compound

المردود 89.0%

Ethyl 2-[4-(2-oxothiolan-3-ylidenemethyl)phenyl]propionate

المردود 89.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux
2. 2
   درجة الحرارةby heating
3. 3
   أخرىThe solvent was evaporated under reduced pressure
4. 4
   أخرىthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1)

الإجراء التجريبي

Ethyl 2-{4-[hydroxy(2-oxothiolan-3-yl)methyl]phenyl}propionate (300 mg) obtained in Example 32 was dissolved in toluene (3.0 ml), and to the solution was added p-toluenesulfonic acid (200 mg), and stirred for 1 hour under reflux by heating. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1) to give the title compound (251 mg, 89%).

المصدر