تفاعل #1772017

معادلة التفاعل

compound 4

N-Methyl-3-pyrrolidinyl cyclopentylmandelate

ethyl bromoacetate

ethyl ether

→

Compound ( b )

3-(2-Cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(ethoxycarbonylmethyl)-1-methylpyrrolidinium bromide

المذيبات

acetonitrile

ethylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of acetonitrile
2. 2
   أخرىgave a crude product
3. 3
   أخرىto precipitate

الإجراء التجريبي

To compound 4 (0.369 g, 1.22 mmol) in 10 ml of dry acetonitrile, ethyl bromoacetate (0.377 g, 2.25 mmol) was added at room temperature. The mixture was stirred for 2 h. Evaporation of acetonitrile gave a crude product. The crude product was dissolved in a small volume of ethylene chloride and then poured into 50 ml of dry ethyl ether to precipitate. This procedure was repeated three times to obtain Compound (b) as pure product (0.45 g, 79%). White powder, m.p.: 192-194° C.

المصدر