تفاعل #1771991
ord-696188d0a22a43afa651f35351c4c027
معادلة التفاعل
Boc-Pro(4,4-diMe)-OH
thionylchloride
methanol
→
4,4-Dimethylproline Methylester Hydrochloride Salt
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1تركيزThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)
الإجراء التجريبي
To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).