تفاعل #1769056

معادلة التفاعل

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride

methanol

thionyl chloride

→

white crystals

المردود 60.0%

1,4,5,6-Tetrahydro-5-methoxycarbonylpyrimidine Hydrochloride

المردود 60.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting solution was refluxed
2. 2
   workup.STIRRINGwith stirring for 18 hours
3. 3
   أخرىevaporated in vacuo to white solids
4. 4
   أخرىThe crude product was recrystallized from anhydrous methanol

الإجراء التجريبي

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride (6.34 g, 38.5 mmol) was dissolved in anhydrous methanol (200 ml) with stirring, and thionyl chloride (2.74 ml, 38.5 mmol) was added dropwise. The resulting solution was refluxed with stirring for 18 hours, then evaporated in vacuo to white solids. The crude product was recrystallized from anhydrous methanol to yield 4.12 g (60%) white crystals, mp 160°-164° C. Calculated: C 40.34, H 6.21, N 15.69; found: C 40.17, H 6.41, N 15.73.

المصدر