تفاعل #1769054

معادلة التفاعل

2-propanol

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride

thionyl chloride

charcoal

→

crystals

المردود 84.0%

Isopropyl 1,4,5,6-Tetrahydropyrimidine-5-carboxylate Hydrochloride

المردود 84.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was refluxed 24 h
2. 2
   أخرىby evaporating unreacted alcohol

الإجراء التجريبي

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride (1.0 g, 6.08 mmol) was suspended in 2-propanol (50 ml) and thionyl chloride (0.76 g, 6.39 mmol) was added dropwise. The resulting mixture was refluxed 24 h. The pink solution was treated with charcoal and then reduced in volume to 15 ml by evaporating unreacted alcohol. By allowing the solution to stand overnight, white crystals (1.08 g, 84%) were obtained in three crops, mp 170° C. 300 MHz nmr confirmed product. Microanalysis calc.: C 46.49, H 7.26, N 13.56, found: C 46.49, H 7.25, N 13.64.

المصدر