تفاعل #1765238

معادلة التفاعل

Sodium hydride

2-aminopropanol

2,6-dichloropyridine

→

yellow oil

المردود 84.2%

1-(6-Chloropyridin-2-yloxy)-2-propylamine

المردود 84.2%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction heated
2. 2
   درجة الحرارةat reflux for 8 hours
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىthe reaction was quenched with aqueous 1N hydrochloric acid
5. 5
   غسيلwashed with ether (3×30 mL)
6. 6
   درجة الحرارةThe pH of the aqueous phase was then raised to 10-11 with 50 wt. percent aqueous sodium hydroxide
7. 7
   استخلاصextracted with ether (3×50 mL)
8. 8
   تجفيفThe organics were dried (MgSO4)
9. 9
   ترشيحfiltered
10. 10
    أخرىsolvent removed in vacuo

الإجراء التجريبي

Sodium hydride (60 wt. percent oil dispersion, 560 mg, 14 mmol) was added to a stirred solution of 2-aminopropanol (1.2 mL, 14 mmol) in THF (25 mL). After 30 minutes, 2,6-dichloropyridine (2.0 g, 14 mmol) was added and the reaction heated at reflux for 8 hours. After cooling, the reaction was quenched with aqueous 1N hydrochloric acid and washed with ether (3×30 mL). The pH of the aqueous phase was then raised to 10-11 with 50 wt. percent aqueous sodium hydroxide and extracted with ether (3×50 mL). The organics were dried (MgSO4), filtered and solvent removed in vacuo leaving 2.2 g of a yellow oil.

المصدر