تفاعل #1764381

معادلة التفاعل

3-Fluoro-4-carboxy-phenylboronic acid

pinacol

→

2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid

المذيبات

Toluene EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith heating
2. 2
   أخرىto give a thick white slurry
3. 3
   تركيزThe mixture was concentrated under reduced pressure, toluene (30 ml)
4. 4
   workup.ADDITIONwas added
5. 5
   تركيزthe mixture was again concentrated under reduced pressure to a white solid
6. 6
   أخرىThe material was dried under high vacuum overnight
7. 7
   أخرىto give 1.42 g

الإجراء التجريبي

3-Fluoro-4-carboxy-phenylboronic acid (CAS 120153-08-4) (1.0 g, 5.4 mmol) and pinacol (0.645 g, 5.4 mmol) were stirred in Toluene/EtOH (1:1) (30 ml) with heating to give a thick white slurry. The mixture was concentrated under reduced pressure, toluene (30 ml) was added and the mixture was again concentrated under reduced pressure to a white solid. LCMS (−ve ion mode) showed a single peak trace with 265 (M−H RP). The material was dried under high vacuum overnight to give 1.42 g.

المصدر