تفاعل #1762014

معادلة التفاعل

6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

2,2-difluoro-1,3-benzodioxole-4-carbaldehyde

→

6-[4-[(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude product was purified by hplc
2. 2
   غسيلeluted with decreasingly polar mixtures of water (containing 1% aqueous ammonia) and acetonitrile as eluents

الإجراء التجريبي

Reductive amination of 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine with 2,2-difluoro-1,3-benzodioxole-4-carbaldehyde was carried out according to General Synthetic Method 5. The crude product was purified by hplc using a Waters XBridge Prep C18 OBD column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.

المصدر