تفاعل #1755476

معادلة التفاعل

methyl 5-nitro-2-furoate

hydrogen

→

methyl 5-amino-2-furoate

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe mixture was filtered through a celite pad
2. 2
   تركيزconcentrated

الإجراء التجريبي

A solution of 100 mg of methyl 5-nitro-2-furoate (Lancaster Synthesis, Windham, N.H., USA) in 20 ml of EtOAc was stirred with 20 mg of Pd/C (10%) under one atmospheric pressure of hydrogen gas. After at RT for 2 hours, the mixture was filtered through a celite pad and concentrated. Pure methyl 5-amino-2-furoate was obtained by purification on a fresh silica gel column eluted with 30% EtOAc in hexane.

المصدر