تفاعل #1755456

معادلة التفاعل

imidazole

methyl 4-fluorobenzoate

potassium carbonate

→

1-(4′-methoxycarbonylphenyl)imidazole

المردود 59.0%

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling to room temperature
2. 2
   ترشيحPrecipitated product is filtered off
3. 3
   غسيلwashed with water

الإجراء التجريبي

A mixture of imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) in DMSO (200 ml) is stirred at 120° C. for 3 h. After cooling to room temperature, the mixture is added to ice-water. Precipitated product is filtered off and washed with water. Yield: 59%.

المصدر