تفاعل #1755

معادلة التفاعل

water

trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol

potassium carbonate

diethylamine

→

trans-O-Acetyl-4-(4-diethylaminomethylphenyl)-cyclohexanol

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture is extracted with methylene chloride
2. 2
   أخرىThe organic phase is dried
3. 3
   أخرىevaporated down in vacuo
4. 4
   أخرىthe residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1)

الإجراء التجريبي

A solution of 1 g (3.75 mmol) of trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol in 10 ml of dimethylformamide is mixed with 0.52 g (3.75 mmol) of potassium carbonate and 0.27 g (3.75 mmol) of diethylamine. This mixture is heated to 50° C. for 6 hours with stirring, then water is added and the mixture is extracted with methylene chloride. The organic phase is dried, evaporated down in vacuo and the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1). Colourless oil.

المصدر