تفاعل #1747870

معادلة التفاعل

10-[4-(N-phenyl-2-benzimidazolyl)phenyl]phenothiazine

m-chloroperbenzoic acid

KOH

→

10-[4-(N-Phenyl-2-benzimidazolyl)phenyl]phenothiazine 5,5-dioxide

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith cooling
2. 2
   أخرىAfter the methylene chloride had been removed
3. 3
   workup.ADDITIONthe suspension was diluted with 100 ml of hot water
4. 4
   ترشيحThe precipitate was filtered off with suction
5. 5
   غسيلwashed with hot water
6. 6
   أخرىdried at 80° C. under reduced pressure
7. 7
   أخرىThe crude product (4.82 g) was recrystallized from 48 ml of acetic acid
8. 8
   أخرىwere obtained

الإجراء التجريبي

A solution of 6.14 g of 10-[4-(N-phenyl-2-benzimidazolyl)phenyl]phenothiazine in 180 ml of methylene chloride was admixed at room temperature with 7.17 g (28.9 mmol) of 70% m-chloroperbenzoic acid with cooling and stirred at room temperature for 1 h. The solution was admixed with 60 ml of 10% KOH. After the methylene chloride had been removed, the suspension was diluted with 100 ml of hot water. The precipitate was filtered off with suction, washed with hot water and dried at 80° C. under reduced pressure. The crude product (4.82 g) was recrystallized from 48 ml of acetic acid. 3.02 g (46% of theory) of beige microcrystals having an m.p. of 286-288° C. were obtained.

المصدر