تفاعل #1747867

معادلة التفاعل

10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide

ammonium formate

→

10-(4-Hydroxyphenyl)phenothiazine 5,5-dioxide

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe solution was filtered
2. 2
   تركيزThe filtrate was concentrated
3. 3
   workup.ADDITIONafter adding 10 ml of methanol
4. 4
   ترشيحThe solid was filtered off with suction
5. 5
   غسيلwashed with methanol
6. 6
   أخرىdried at 110° C. in a vacuum
7. 7
   أخرىdrying cabinet
8. 8
   أخرىwere obtained

الإجراء التجريبي

3.10 g (7.50 mmol) of 10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide, 2.30 g (35.7 mmol) of 98% ammonium formate and 7.5 g of 10% palladium on activated carbon were heated to boiling under reflux in 225 ml of acetone for 1 hour. After cooling to room temperature, the solution was filtered. The filtrate was concentrated and, after adding 10 ml of methanol, stirred overnight. The solid was filtered off with suction, washed with methanol and dried at 110° C. in a vacuum drying cabinet. 1.47 g (61% of theory) of analytically pure light gray microcrystals having an m.p. of 308-311° C. were obtained.

المصدر